First, you want to grind your pistachios into almost a flour. Not too fine because you want some texture but just coarsely ground. You can use a food processor, smoothie blender or high powered blender. In a pinch, you can even use a coffee grinder or a resealable bag and rolling pin to crush pistachios.
Add garlic powder, onion powder, a dash of cayenne (if using), salt and pepper to pistachio mix and combine. Add to a plate shallow enough to dredge chicken. Brush chicken breasts with Dijon mustard and roll both sides in pistachio spice mix. Once chicken is breaded, refrigerate for 10-minutes before cooking.
Preheat oven to 425 degrees F. To a shallow baking dish or parchment lined baking sheet, bake chicken 16-20 minutes, until internal temperature reaches 165 degrees F.